Transition to HBeAg-negative chronic hepatitis B virus infection is associated with reduced cccDNA transcriptional activity
نویسندگان
چکیده
منابع مشابه
Comparison of Serum Hepatitis B Virus DNA and HBsAg Levels Between HBeAg-Negative and HBeAg-Positive Chronic Hepatitis B Patients
BACKGROUND Chronic hepatitis B consists of different clinical phases. Laboratory and histological assessments can help differentiate the clinical phases of this disease and thus lead to better management. OBJECTIVES This study was conducted to determine laboratory and histological characteristics of HBeAg-negative and HBeAg-positive chronic hepatitis B patients. PATIENTS AND METHODS In this...
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Previous mutation based studies showed that ablating synthesis of viral envelope proteins led to elevated hepadnaviral covalently closed circular DNA (cccDNA) amplification, but it remains unknown how cccDNA amplification is regulated in natural hepadnaviral infection because of a lack of research system. In this study we report a simple procedure to prepare two identical duck hepatitis B virus...
متن کاملDifferential Plasma MicroRNA Profiles in HBeAg Positive and HBeAg Negative Children with Chronic Hepatitis B
BACKGROUND AND AIM Children chronically infected with hepatitis B virus (HBV) are at high risk of progressive liver disease. However, no treatment is available that is consistently effective in curing chronic hepatitis B (CHB) in children. Improved understanding of the natural course of disease is warranted. Identification of specific microRNA (miRNA) profiles in children chronically infected w...
متن کاملPresence of HBV-DNA in cord blood is associated with spontaneous preterm birth in pregnant women with HBeAg-negative chronic hepatitis B virus infection.
Spontaneous preterm birth is the leading cause of perinatal morbidity and mortality. In this study the spontaneous preterm birth rates in a group of hepatitis B e antigen (HBeAg)-negative chronic hepatitis B virus (HBV)-infected pregnant women without known risk factors for preterm delivery as well as the role of maternal laboratory data and hepatitis B surface antigen/HBV deoxyribonucleic acid...
متن کاملcomparison of serum hepatitis b virus dna and hbsag levels between hbeag-negative and hbeag-positive chronic hepatitis b patients
background chronic hepatitis b consists of different clinical phases. laboratory and histological assessments can help differentiate the clinical phases of this disease and thus lead to better management. objectives this study was conducted to determine laboratory and histological characteristics of hbeag-negative and hbeag-positive chronic hepatitis b patients. patients and methods in this stu...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2021
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2020.11.003